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Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1

✍ Scribed by Tamás Hegedűs; László Őrfi; Attila Seprődi; András Váradi; Balázs Sarkadi; György Kéri

Book ID
117617916
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
166 KB
Volume
1587
Category
Article
ISSN
0925-4439

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The ATP-binding cassette (ABC) transporter ABCC1, or multidrug resistance-related protein 1 (MRP1) is implicated in Phase II metabolism and multidrug resistance as it effluxes substrate anticancer drugs. As cannabinoids inhibit two related ABC transporters, P-glycoprotein and ABCG2, here we examined