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Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein

โœ Scribed by Tanja Peters; Heike Lindenmaier; Walter E. Haefeli; Johanna Weiss


Book ID
105876477
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
218 KB
Volume
372
Category
Article
ISSN
0028-1298

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X-Ray Structure, Conformational Analysis
โœ C.Oliver Kappe; Oleg V Shishkin; Georg Uray; Petra Verdino ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 108 KB

The conformational features of the mitotic kinesin Eg5 inhibitor monastrol were investigated by computational (AM1, HF/3-21G โ€ซุกโ€ฌ ), X-ray diffraction, and NMR studies showing that monastrol is a conformationally highly flexible molecule. Racemic monastrol was resolved by direct enantioselective HPLC