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Interaction of the Mitotic Inhibitor Monastrol with Human Kinesin Eg5 †

✍ Scribed by DeBonis, Salvatore; Simorre, Jean-Pierre; Crevel, Isabelle; Lebeau, Luc; Skoufias, Dimitrios A.; Blangy, Anne; Ebel, Christine; Gans, Pierre; Cross, Robert; Hackney, David D.; Wade, Richard H.; Kozielski, Frank

Book ID
120269418
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
315 KB
Volume
42
Category
Article
ISSN
0006-2960

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X-Ray Structure, Conformational Analysis
X-Ray Structure, Conformational Analysis, Enantioseparation, and Determination of Absolute Configuration of the Mitotic Kinesin Eg5 Inhibitor Monastrol
✍ C.Oliver Kappe; Oleg V Shishkin; Georg Uray; Petra Verdino 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 108 KB

The conformational features of the mitotic kinesin Eg5 inhibitor monastrol were investigated by computational (AM1, HF/3-21G ‫ء‬ ), X-ray diffraction, and NMR studies showing that monastrol is a conformationally highly flexible molecule. Racemic monastrol was resolved by direct enantioselective HPLC