Interaction of pharmaceuticals with schardinger dextrins II. Interaction with selected compounds

✍ Scribed by John L. Lach; Jack Cohen

• Publisher: John Wiley and Sons
• Year: 1963
• Tongue: English
• Weight: 370 KB
• Volume: 52
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600520207

✦ Synopsis

Data for the interaction of the Schardinger dextrins with 19 pharmaceuticals in aqueous solution are presented. All the compounds interact with both alpha and beta cyclodextrin. Data are presented to show that the less soluble the drug is in water, the greater is its per cent increase in solubility as a function of cyclodextrin concentration. Comparison of the isothermal slopes of the interactions shows that the largest molecules show the smallest slopes and therefore the smallest degree of interaction with the cyclodextrins. Molecular structure is a very important factor in the interaction which is believed to be a combination of inclusion formation and other intermolecular attractive forces.

HE PHENOMENON of complexation has become