## Abstract To evaluate the involvement of the expression of parathyroid hormoneβrelated peptide gene in human articular cartilage pathology, we performed immunohistochemical staining and __in situ__ hybridization on specimens of femoral head cartilage obtained from 15 patients with osteoarthritis,
Interaction of parathyroid hormone and of parathyroid hormone-related peptide with target cells in the skeleton
β Scribed by D. Goltzman
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 654 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0914-8779
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
ROS17/2.8 cells, a cell line derived from a rat osteosarcoma, have abundant receptors for parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). A particulate membrane fraction was prepared from these cells and it was solubilized using relatively mild conditions with digitonin (0
It is becoming increasingly apparent that parathyroid hormone-related peptide (PTHrP) modulates cellular function in a dual mode of action: first, by binding and activating its cognate cell surface G-protein-coupled receptor and, second, by direct intracellular effects following translocation to the
## Abstract Parathyroid hormoneβrelated peptide (PTHrP) and parathyroid hormone (PTH)/PTHrPβreceptor, PTH/PTHrPβR, are frequently expressed in mammary carcinomas as well as in bone cells. In this study we compared the ligand binding characteristics of the PTH/PTHrPβR in SaOSβ2 human osteosarcoma ce