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Interaction of onconase with the human ribonuclease inhibitor protein

✍ Scribed by Rebecca F. Turcotte; Ronald T. Raines


Book ID
116297590
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
295 KB
Volume
377
Category
Article
ISSN
0006-291X

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Ribonuclease A (RNase A) and the ribonuclease inhibitor protein (RI) form one of the tightest known protein-protein complexes. RNase A variants and homologues, such as G88R RNase A, that retain ribonucleolytic activity in the presence of RI are toxic to cancer cells. Herein, a new and facile assay i