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Interaction of Novel Ibogaine Analogs With The Human α3β4 Nicotinic Receptor

✍ Scribed by Coleman, Benjamin P.; Sarrami, Samira; Arias, Hugo R.


Book ID
119204611
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
56 KB
Volume
96
Category
Article
ISSN
0006-3495

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A novel series of [3.2.1] azabicyclic bi
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We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of a3and a6-containing nicotinic receptors. In particular, compound 17a from this series is a potent a3b4 and a6/4b4 receptor agonist in terms of both binding and functional activity. Compound 17a also show