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Interaction of multiple sclerosis serum with liposomes containing ganglioside GM1

✍ Scribed by Dr. Brian R. Mullin; Anthony J. Montanaro; J. D. Reid; Robert N. Nishimura

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 321 KB
Volume: 7
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410070615

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Multiple sclerosis serum contains a factor or factors capable of releasing sequestered [^14^C]glucose from liposomes containing G~M1~, the major ganglioside present in human central nervous system myelin. Although some control sera can also release large quantities of liposomal glucose, multiple sclerosis and control sera differ in the mechanism of this release. Liposomal damage by multiple sclerosis serum does not appear to be complement mediated, but shares certain releasing characteristics of cholera toxin.

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