Interaction of interferon with other immunomodulators regulating human natural killer cell activity
β Scribed by S. B. Cheknev; O. L. Latysheva; L. A. Denisov; F. I. Ershov
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 318 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0007-4888
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## Abstract Fresh neoplastic B cells from 14 untreated patients with naturally occurring Bβcell leukemias were found to be susceptible to lysis by human natural killer (NK) cells. The observed lysis of the fresh, nonβcultured, neoplastic B cells was mediated by a population of interferonβaugmentabl
## Abstract Nonβtoxic concentrations of retinoic acid (RA) inhibited the spontaneous activity of human natural killer (NK) cells. RA also inhibited the activation of human NK cells by treatment with partially purified human leukocyte interferon (HulFNΞ±) or with inducers of IFNΞ± and IFNΞ³. Full expre