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Interaction of Copper (II) complexes with pBR322 DNA

✍ Scribed by S.M. Morehouse; J. Cronin; L. Gomba; C .Cooper; G. Perna

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
75 KB
Volume
43
Category
Article
ISSN
0162-0134

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Double-helical metal complexes, the helicates H2-Hs, were found to bind to double-helical DNA by spectroscopic, DNA-melting, and electrophoretic-mobility measurements. The helicates also inhibited the cleavage of DNA by two restriction enzymes, SspI and EcoRV, a property which agrees with the bindin