✦ LIBER ✦

Interaction of 5-fluoro-4-thio-2′-deoxyuridine 5′-phosphate with mammalian tumour thymidylate synthase: Role of the pyrimidine N(3)-H dissociation

✍ Scribed by Jolanta M. Dzik; Tadeusz Kulikowski; Zbigniew Zielinski; Joanna Ciesla; Wojciech Rode; David Shugar

Book ID: 115760252
Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 517 KB
Volume: 149
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(87)90535-3

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Studies on the interaction with thymidyl

Studies on the interaction with thymidylate synthase of analogues of 2′-deoxyuridine-5′-phosphate and 5-fluoro-2′-deoxyuridine-5′-phosphate with modified phosphate groups

✍ Wojciech Rode; Tadeusz Kulikowski; Barbara Kedzierska; David Shugar 📂 Article 📅 1987 🏛 Elsevier Science 🌐 English ⚖ 859 KB

Interaction of Thymidylate Synthase with

Interaction of Thymidylate Synthase with the 5-Thiophosphates, 5-Dithiophosphates, 5-H-Phosphonates and 5-S-Thiosulfates of 2-Deoxyuridine, Thymidine and 5-Fluoro-2-Deoxyuridine

✍ Golos, B.; Dzik, J.M.; Kazimierczuk, Z.; Ciesla, J.; Zielinski, Z.; Jankowska, J 📂 Article 📅 2001 🏛 Walter de Gruyter GmbH & Co. KG 🌐 English ⚖ 140 KB

Interaction of 2-Thio-5-fluoro-dUMP and

Interaction of 2-Thio-5-fluoro-dUMP and 4-Thio-5-fluoro-dUMP with Mammalian Normal and Tumor and Helminthic Thymidylate Synthases: Influence of C(4)-Substituents on Specificity for Enzyme Inactivation

✍ J.M. Dzik; Z. Zielinski; J. Ciesla; M. Bretner; T. Kulikowski; D. Shugar; J.R. B 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 395 KB

Crystal structures of 5-fluoro-dUrd and

Crystal structures of 5-fluoro-dUrd and its 2 and/or 4-thio analogues: models of substituted dUMP pyrimidine ring interacting with thymidylate synthase

✍ Adam Jarmuła; Romana Anulewicz; Andrzej Leś; Michał K Cyrański; Ludwik Adamowicz 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 116 KB

Synthesis of N-{4-[(2,4-Diamino-5-methyl

Synthesis of N-{4-[(2,4-Diamino-5-methyl-4,7-dihydro-3H- pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-l-glutamic Acid and N-{4-[(2-Amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin- 6-yl)thio]benzoyl}-l-glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase and as Potential Antitumor Agents

✍ Gangjee, Aleem; Lin, Xin; Kisliuk, Roy L.; McGuire, John J. 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 561 KB

X-ray Crystal andAb InitioStructures of

X-ray Crystal andAb InitioStructures of 3′,5′-di-O-Acetyl-N(4)-Hydroxy-2′-Deoxycytidine and Its 5-Fluoro Analogue: Models of theN(4)-OH-dCMP andN(4)-OH-FdCMP Molecules Interacting with Thymidylate Synthase

✍ Adam Jarmuła; Wojciech R. Rypniewski; Krzysztof Felczak; Wojciech Rode 📂 Article 📅 2005 🏛 Springer 🌐 English ⚖ 150 KB