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Interaction of 2-deamino- and 2-deamino-2-nitroactinomycin D with calf-thymus DNA and formation of ion-radicals

✍ Scribed by Raj K. Sehgal; Donna L. Greenwood; Sisir K. Sengupta


Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
615 KB
Volume
13
Category
Article
ISSN
0045-2068

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The interaction of Mg2+, Ca2+, Zn2+, and Cd2' with calf thymus DNA has been investigated by Raman spectroscopy. These spectra reveal that all of these ions, and particularly Zn2+, bind to phosphate groups of DNA, causing a slight structural change in the polynucleotide at very small metal : D N A (