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Interaction Between Valproic Acid and Carbapenem Antibiotics

โœ Scribed by Mori, Hitomi; Takahashi, Kazuhiko; Mizutani, Takaharu

Book ID
121399848
Publisher
Informa plc
Year
2007
Tongue
English
Weight
206 KB
Volume
39
Category
Article
ISSN
0360-2532

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Carbapenem antibiotics cause pharmacokinetic interaction with valproic acid (VPA) in clinical pharmacotherapy. Here, we investigated the mechanism of interaction from the viewpoint of erythrocyte distribution of VPA in rats and humans. Imipenem or panipenem was administered intravenously and then VP