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Interaction between trimethoprim-sulfamethoxazole and methotrexate in children with leukemia

✍ Scribed by Gianmario Ferrazzini; Julla Klein; Hassan Sulh; Derrick Chung; Esther Griesbrecht; Gideon Koren

Book ID
117163879
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
319 KB
Volume
117
Category
Article
ISSN
1097-6833

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## Abstract From 1972 ‐ 1974, 228 children began treatment for acute lymphocytic leukemia and were prospectively assessed for neurologic complications. After CNS irradiation (2,400 rad) and intrathecal methotrexate (MTX), they received weekly intravenous maintenance therapy with MTX alone (40–60 mg