Interaction between erbB- receptors and heregulin in breast cancer tumor progression and drug resistance
β Scribed by Ruth Lupu; Marina Cardillo; Lyndsay Harris; Mai Hijazi; Karen Rosenberg
- Book ID
- 112264811
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 106 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1044-579X
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The responsiveness of estrogen receptor (ER)-positive breast cancer to endocrine therapy is frequently reduced in cells over-expressing c-erbB-2. Stimulation of ER suppresses c-erbB-2, indicating that estrogen controls the activity of c-erbB-2. Heregulin (HRG) has been described to bind to c-erbB-3/
Expression of c-erbB-2 protein has been associated with poor prognosis and poor response to chemotherapy in breast cancer patients. In the present prospective study, we have analyzed whether c-erbB-2, p53 and P170 proteins may be determinants of tumor resistance in locally advanced breast cancer pat