Expression of erbB/HER receptors, heregulin and p38 in primary breast cancer using quantitative immunohistochemistry
β Scribed by Francisco J. Esteva; Gabriel N. Hortobagyi; Aysegul A. Sahin; Terry L. Smith; Dot Mon Chin; Shang -Ying Liang; Lajos Pusztai; Aman U. Buzdar; Sarah S. Bacus
- Book ID
- 105698992
- Publisher
- Springer Netherlands
- Year
- 2001
- Tongue
- English
- Weight
- 812 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1219-4956
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A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcoholformalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC).
## Abstract Accurate assessment of estrogen receptor (ER), progesterone receptor (PR), and Her2 status of breast carcinomas is critical for predicting response to systemic therapies. Recently, developed rabbit monoclonal antibodies (RMab) are reported to have higher sensitivity than murine monoclon