## Abstract The insulin receptor substrateโ1 (IRSโ1) and cโmet, the receptor for the hepatocyte growth factor (HGF) coโimmunoโprecipitate from lysates treated with the respective antibodies. The interaction between IRSโ1 and cโmet requires a tyrosyl phosphorylated IRSโ1 and results in reciprocal do
โฆ LIBER โฆ
Interaction between Brk kinase and insulin receptor substrate-4
โ Scribed by Qiu, Haoqun; Zappacosta, Francesca; Su, Wenjuan; Annan, Roland S; Miller, W Todd
- Book ID
- 110069767
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 279 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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Insulin causes rapid phosphorylation of the fl subunit (M, = 95,000) of its receptor in broken cell preparations. This occurs on tyrosine residues and is due to activation of a protein kinase which is contained in the receptor itself. In the intact cell, insulin also stimulates the phosphorylation o