Fifteen years ago BRCA1 and BRCA2 were reported as high penetrant breast cancer predisposing genes. However, mutations in these genes are found in only a fraction of high risk families. BARD1 is a candidate breast cancer gene, but only a limited number of missense mutations with rather unclear patho
Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2
โ Scribed by Wong, Johnson M S; Ionescu, Daniela; Ingles, C James
- Book ID
- 110067200
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 300 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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We have developed a 2-stage protocol for BRCA1 and BRCA2 mutation screening from blood spot paper. Stage 1 screening was aimed to analyze patients at highest risk for the most common disease-associated sequence variants listed in the BIC database. Accordingly, stage1 testing implied detection of 18