Previous mutational analysis for BRCA gene mutations in sporadic ovarian cancer occurring in Chinese patients in Hong Kong identified six germline BRCA1 mutations and one germline BRCA2 mutation, six of which were novel (Khoo et al., 2000). Knowledge of BRCA gene mutations in the Chinese population
A BRCA2 founder mutation and seven novel deleterious BRCA mutations in southern Chinese women with breast and ovarian cancer
β Scribed by Ava Kwong; L. P. Wong; H. N. Wong; F. B. F. Law; E. K. O. Ng; Y. H. Tang; W. K. Chan; L. S. Ho; K. H. Kwan; M. Poon; T. T. Wong; F. C. S. Leung; S. W. W. Chan; M. W. L. Ying; E. S. K. Ma; J. M. Ford
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 164 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0167-6806
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Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact o
We have investigated the impact of BRACA1 and BRACA2 mutations that were frequently identified among Hungarian high-risk breast-ovarian cancer families (Ramus et al., 1997b, AJHG), on the development of breast and ovarian cancer in the general Hungarian population. The prevalence of 3 BRCA1 mutation