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Interaction and Lipid-Induced Conformation of Two Cecropin−Melittin Hybrid Peptides Depend on Peptide and Membrane Composition

✍ Scribed by Abrunhosa, Filipa; Faria, Sílvia; Gomes, Paula; Tomaz, Isabel; Pessoa, João C.; Andreu, David; Bastos, Margarida


Book ID
125899825
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
239 KB
Volume
109
Category
Article
ISSN
0022-3654

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A 15-residue hybrid peptide ( KWKLFKKIGAVLKVL-amide) incorporating partial sequences of cecropin A and melittin causes the release of carboxyfluoresceine encapsulated in phosphatidylcholine liposomes. Succinylation of the amino groups in the N-terminus and lysine side chains inhibits the effect of t