✦ LIBER ✦

INTEGRINS ALPHA 3 AND ALPHA 6 ARE DIFFERENTIALLY EXPRESSED IN ENDOMETRIUM AND ENDOMETRIOSIS

✍ Scribed by RAI, VIKRAM; HOPKISSON, JAMES; KENNEDY, STEPHEN; BERGQVIST, AGNETA; BARLOW, DAVID H.; MARDON, HELEN J.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 1002 KB
Volume: 180
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199610)180:2<181::aid-path620>3.0.co;2-i

No coin nor oath required. For personal study only.

✦ Synopsis

The expression of integrin subunits has been investigated in the stroma and epithelium of eutopic and ectopic endometrial tissues, using immunohistochemistry and fluorescently activated cell-sorting techniques. Integrin subunits exhibited tissue-specific expression in both eutopic and ectopic endometrium. Integrin a3 subunit was up-regulated in ectopic endometrium compared with the eutopic counterpart, whereas a6 integrin subunit was down-regulated in the ectopic tissues. Cycle stage-dependent expression of av and p3, observed in eutopic endometrium, was absent in the ectopic counterpart. It is concluded that the development and regeneration of the endometrium involve complex integrin-ligand interactions and that regulation of specific adhesive events is lost in endometriosis.

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