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Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels

✍ Scribed by Dennis Hallahan; Ling Geng; Shimian Qu; Christopher Scarfone; Todd Giorgio; Edwin Donnelly; Xiang Gao; Jeff Clanton

Book ID
114413262
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
711 KB
Volume
3
Category
Article
ISSN
1535-6108

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## Abstract The irregular vasculature and high interstitial pressure of solid tumors hinder the delivery of cytotoxic agents to cancer cells. As a consequence, the doses of chemotherapy necessary to achieve complete tumor eradication are associated with unacceptably high toxicities. The selective t