𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Integration Specificity of Phage ϕC31 Integrase in the Human Genome

✍ Scribed by Thomas W. Chalberg; Joylette L. Portlock; Eric C. Olivares; Bhaskar Thyagarajan; Patrick J. Kirby; Robert T. Hillman; Juergen Hoelters; Michele P. Calos

Book ID
116662707
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
968 KB
Volume
357
Category
Article
ISSN
0022-2836

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Phage ϕC31 integrase-mediated genomic in
Phage ϕC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines
✍ Yoshinori Ishikawa; Nobuyuki Tanaka; Kazuhiro Murakami; Toru Uchiyama; Satoru Ku 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB

## Abstract ## Background X‐linked severe combined immunodeficiency (SCID‐X1, X‐SCID) is a life‐threatening disease caused by a mutated common cytokine receptor γ chain (γc) gene. Although __ex vivo__ gene therapy, i.e., transduction of the γc gene into autologous CD34^+^ cells, has been successfu

Phage phiC31 integrase-mediated genomic
Phage phiC31 integrase-mediated genomic integration and long-term gene expression in the lung after nonviral gene delivery
✍ Manish Kumar Aneja; Rabea Imker; Carsten Rudolph 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 723 KB

## Abstract ## Background Phage ϕC31 integrase has emerged as a potent tool for achieving long‐term gene expression in different tissues. The present study investigated the activity of ϕC31 integrase in murine lungs. ## Methods Transfections in murine alveolar epithelial (MLE12) cells were perfo