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Identification of pseudo attP sites for phage ϕC31 integrase in bovine genome

✍ Scribed by Qing-wen Ma; Hai-qing Sheng; Jing-bin Yan; Shan Cheng; Ying Huang; Yanru Chen-Tsai; Zhao-rui Ren; Shu-zhen Huang; Yi-tao Zeng

Book ID: 116292899
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 151 KB
Volume: 345
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2006.04.145

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## Abstract ## Background X‐linked severe combined immunodeficiency (SCID‐X1, X‐SCID) is a life‐threatening disease caused by a mutated common cytokine receptor γ chain (γc) gene. Although __ex vivo__ gene therapy, i.e., transduction of the γc gene into autologous CD34^+^ cells, has been successfu