Integration of the PRB and P53 Cell Cycle Control Pathways
β Scribed by Craig L. Stewart; Alejandro Moro Soria; Paul A. Hamel
- Book ID
- 110292513
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 173 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0167-594X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Mice lacking both p18 Ink4c and p27 Kip1 develop a tumor spectrum similar to pRb ΓΎ/Γ mice, and loss of p53 function accelerates tumorigenesis in pRb ΓΎ/Γ mice. We hypothesized that codeletion of either p18 or p27 in conjunction with p53 deletion will also accelerate tumorigenesis. Mice lacking both p
## Abstract A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains highβrisk human papillomavirusβtype 16 (HPV16). The viral E6 and E7 oncoproteins inactivate the p53 and pRb proteins, respectively. We examined the causative effect of HPV16 E6 and E7 expression on the immortalizatio