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Integration of in vitro data and brain weight in allometric scaling to predict clearance in humans: Some suggestions

✍ Scribed by Iftekhar Mahmood

Book ID
109388903
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
30 KB
Volume
87
Category
Article
ISSN
0022-3549

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This study was conducted to comprehensively evaluate the performance of various allometric scaling methods for the prediction of human clearance. Allometric scaling was used to predict clearance for 103 compounds, for which clearance data in the rat, dog, monkey, and humans were available. Allometry

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In Table 3, the MAE value for three-species allometric scaling using the rule of exponents should be 6.44, not 11.03 as originally cited. This error resulted from an incorrect predicted value for one of the 103 compounds in the dataset (nicotine; incorrect error of 479.6 mL/min/kg rather than the co