Integrating Adhesion, Protrusion, and Contraction during Cell Migration
β Scribed by Martin A. Schwartz; Alan Rick Horwitz
- Book ID
- 116353145
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 81 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0092-8674
No coin nor oath required. For personal study only.
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Migrating cells form dynamic and highly regulated adhesive interactions with their environment. In particular, integrin-mediated adhesions to the extracellular matrix (ECM) play a central role in cell migration. This review focuses on recent advances in understanding the adhesive mechanisms that reg
## Abstract Many cells display dramatically different morphologies when migrating in 3D matrices vs. on planar substrata. How these differences arise and the implications they have on cell migration are not well understood. To address these issues, we examined the locomotive structure and behavior