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Regulation of integrin-mediated adhesion during cell migration

✍ Scribed by Cox, Elisabeth A.; Huttenlocher, Anna

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
184 KB
Volume
43
Category
Article
ISSN
1059-910X

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✦ Synopsis

Migrating cells form dynamic and highly regulated adhesive interactions with their environment. In particular, integrin-mediated adhesions to the extracellular matrix (ECM) play a central role in cell migration. This review focuses on recent advances in understanding the adhesive mechanisms that regulate cell detachment at the rear of migrating fibroblasts and neutrophils. The contribution of several key adhesive regulators is discussed, including myosin mediated cell contractility, tyrosine phosphorylation, rho, calcium fluxes, and calpain. A challenge for future investigation will be to determine how adhesive events are spatially and temporally coordinated to promote productive directional cell movements.

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