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Integrated pharmacokinetics and pharmacodynamics of atropine in healthy humans II: Pharmacodynamics

✍ Scribed by Peter H. Hinderling; Ursula Gundert-Remy; Olga Schmidliny; Günther Heinzel

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
829 KB
Volume
74
Category
Article
ISSN
0022-3549

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✦ Synopsis

This study determined the kinetics of the effects of atropine on heart rate and saliva flow in three healthy male volunteers after intravenous administration of 1.35 and 2.15 mg of the drug. The pharmacokinetics of atropine and its primary metabolite, tropine, were determined simultaneously. Both the pharmacokinetic and effect data were fitted to an integrated kinetic-dynamic model. The maximum heart rate and minimum saliva flow occurred with a significant delay of 7-8 rnin after drug administration. Both effects were nonlinearly related to the amount of drug in the peripheral compartment. Maximum heart rates of 192 and 217% of the control values were observed at the lower and

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