This study determined the kinetics of the effects of atropine on heart rate and saliva flow in three healthy male volunteers after intravenous administration of 1.35 and 2.15 mg of the drug. The pharmacokinetics of atropine and its primary metabolite, tropine, were determined simultaneously. Both th
Integrated pharmacokinetics and pharmacodynamics of atropine in healthy humans I: Pharmacokinetics
β Scribed by Peter H. Hinderling; Ursula Gundert-Remy; Olga Schmidlin
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 864 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Object&e: To study the possibility that the penetration of the antibiotic ciprofloxacin into polymorphonuclear leukocytes (PMN) may be associated with some changes in cell reactivity. Design: Superoxide anion and chemkminescence generation induced by formyl-methionyl-leucylphenylalanine (fMLP) and p
The objective of this study was to characterize the clinical pharmacokinetic profile of lofexidine after oral delivery. A single dose, cross-over study and a multidose study using healthy volunteers were conducted for that purpose. In the single dose study the average time to maximum concentration w
Amisulpride binds selectively to dopamine D(2) and D(3) receptors in the limbic system. Low doses of amisulpride preferentially block presynaptic D(2)/D(3)-dopamine autoreceptors, thereby enhancing dopaminergic transmission, whereas higher doses block postsynaptic receptors, thus inhibiting dopamine