Integrated detection and population-genetic analysis of SNPs and copy number variation
โ Scribed by McCarroll, Steven A; Kuruvilla, Finny G; Korn, Joshua M; Cawley, Simon; Nemesh, James; Wysoker, Alec; Shapero, Michael H; de Bakker, Paul I W; Maller, Julian B; Kirby, Andrew
- Book ID
- 109914328
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 532 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng.238
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The use of array technology to define chromosome deletions and duplications is bringing us closer to establishing a genotype/phenotype map of genomic copy number alterations. We studied 21 patients and five relatives with deletions of the short arm of chromosome 20 using the Illumina HumanHap550 SNP
## Abstract We performed an integrated array comparative genomic hybridization (aCGH) and expression microarray analysis of 8 normal gastric tissues and 38 primary tumors, including 25 intestinal and 13 diffuse gastric adenocarcinomas to identify genes whose expression is deregulated in association