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Insulin release by d-glucose anomers in a non-insulin-dependent diabetes rat model

โœ Scribed by Niki, Atsushi; Niki, Hatsumi; Hashioka, Toshiki; Niki, Ichiro; Suzuki, Kenichi; Goto, Yoshio


Book ID
122385264
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
503 KB
Volume
7
Category
Article
ISSN
0168-8227

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The effects of the alpha and beta anomers of D-glucose on insulin release were studied in a rat model of non-insulin-dependent diabetes, which was induced by streptozotocin injection at 2 days of age. Glucose tolerance of the streptozotocin-treated rats at 8-10 weeks of age was mildly diabetic. Insu

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A B-cell-deficient model for Type 2 (non-insulindependent) diabetes mellitus has been investigated with regard to insulin action at the cellular level. Two-day-old male Sprague Dawley rats were injected with streptozotocin (90 mg/kg) or citrate buffer. At 6 weeks streptozotocin-treated animals were