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Insulin Receptors in the Liver: Specific Binding of [125I]insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

✍ Scribed by Pierre Freychet, Jesse Roth and David M. Neville

Book ID
123650719
Publisher
National Academy of Sciences
Year
1971
Tongue
English
Weight
797 KB
Volume
68
Category
Article
ISSN
0027-8424

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In the presence of anti-insulin antibody, 2-to 3-fold enhancement of 1251-insulin binding to liver membranes was observed when binding was estimated by the radioactivity of 125I-insulin bound to the membrane pellets. However, after 125I-insulin was covalently cross-linked to liver membranes using di