We describe three siblings with a mild diabetes mellitus in combination with acanthosis nigricans and multiple minor physical abnormalities. Fasting plasma insulin was elevated up to 100-fold as compared with normal values, and the diabetes was classified as insulin resistant. Insulin-binding studie
Glucose binds to the insulin receptor affecting the mutual affinity of insulin and its receptor
✍ Scribed by Robert Root-Bernstein; Jessica Vonck
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 477 KB
- Volume
- 66
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
In the presence of anti-insulin antibody, 2-to 3-fold enhancement of 1251-insulin binding to liver membranes was observed when binding was estimated by the radioactivity of 125I-insulin bound to the membrane pellets. However, after 125I-insulin was covalently cross-linked to liver membranes using di
Insulin receptors are disulfide-linked oligotetramers composed of two heterodimers each containing a 130-kDa 01 subunit and a 90-kDa p subunit. Insulin binds to the extracellular 01 subunit, and in the process stimulates the autophosphorylation of the p subunit and the expression of tyrosine kinase