Insulin-like growth factoristimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells
โ Scribed by D.B. Badesch; P.D.K. Lee; W.C. Parks; K.R. Stenmark
- Book ID
- 115761915
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 505 KB
- Volume
- 160
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Heparin (HP) inhibits pulmonary artery smooth muscle cell (PASMC) growth in vitro and vascular remodeling in vivo. Bรขrzu et al. (1994) suggested that the antiproliferative effect of HP on rat aortic smooth muscle cell in vitro diminishes with prolonged exposure to heparin. We exposed cu
Smooth muscle cell (SMC) hyperplasia is an important component of vascular remodeling in chronic hypoxic pulmonary hypertension. The mechanisms underlying SMC proliferation in the remodeling process are poorly understood, but may involve insulin-like growth factor I (ICF-I). This study investigates