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Insulin-like growth factor signaling pathways in rat hepatic stellate cells: Importance for DNA synthesis and hepatocyte growth factor production

✍ Scribed by S. Skrtic; K. Wallenius; A.M. Gressner; J.-O. Jansson

Book ID
119525990
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
71 KB
Volume
32
Category
Article
ISSN
0168-8278

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Insulin and insulin-like growth factor (IGF-1) are mitogenic for fibroblasts and smooth muscle cells. IGF-1 increases in inflamed and fibrotic tissues and induces proliferation of rat hepatic stellate cells (HSC). This study evaluates the potential roles of these hormones in the development of liver