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Insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced but not basal proliferation and adhesion of LIM 1215 colon cancer cells

✍ Scribed by Sweet L. Leng; Kerri S. Leeding; Robert H. Whitehead; Leon A. Bach


Book ID
117462639
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
579 KB
Volume
174
Category
Article
ISSN
0303-7207

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Limited proteolysis of insulin-like-growth-factor (IGF)-binding proteins (IGFBPs) represents a key process to modulate IGF bio-availability at the cellular level. In human colon carcinomas, urokinase-type plasminogen activator (u-PA) produced by stroma cells can bind to cancer-cell-associated u-PA r