Effects of Insulin-like Growth Factor (IGF) Binding Proteins (BPs)-3 and -6 on DNA Synthesis of Rat Osteoblasts: Further Evidence for a Role of Auto-/Paracrine IGF I but Not IGF II in Stimulating Osteoblast Growth

Stimulatory effect of a phorbol ester on

Stimulatory effect of a phorbol ester on expression of insulin-like growth factor (IGF) binding protein-2 and level of IGF-I receptors in mouse osteoblastic MC3T3-E1 cells

✍ Yoshiyuki Hakeda; Kenji Yoshizawa; Marja Hurley; Hiroshi Kawaguchi; Ken-Ichi Tez 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 776 KB

## Abstract We examined the relationship between signal transduction and the expression of insulin‐like growth factor I (IGF‐I), IGF‐I receptor level, and IGF binding proteins (IGFBPs) in murine clonal osteoblastic MC3T3‐E1 cells. 12–O‐Tetradecanoylphorbol‐13‐acetate (TPA), an activator of protein