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Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells

✍ Scribed by Nicole M. Kühl; Dick Hoekstra; Hans De Vries; Jacques De Keyser

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
290 KB
Volume
44
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

Insulin‐like growth factor 1 (IGF‐1) is a growth and survival factor for oligodendrocyte lineage cells and promotes myelination. We demonstrate that IGF‐binding protein 6 (IGFBP‐6) is expressed and localized to the Golgi complex in rat oligodendrocyte precursor (O2A) cells. IGFBP‐6 mRNA showed a developmentally regulated expression pattern, displaying a transient decrease during early development, and enhanced levels upon cell maturation. IGFBP‐6 mRNA expression could be reduced by addition of basic fibroblast growth factor and progesterone while estrogen increased IGFBP‐6 mRNA. IGF‐1, platelet‐derived growth factor, and insulin had no effect. When added exogenously, IGFBP‐6 reduced O2A cell survival in the absence of IGF‐1 and inhibited IGF‐1‐stimulated survival in a partially IGF‐1‐dependent and partially IGF‐1‐independent fashion. In addition, IGFBP‐6 reduced the IGF‐stimulated expression of two myelin proteins, CNPase and MAG. Taken together, the data show that IGFBP‐6 is a new negative effector of oligodendrocyte survival and differentiation. © 2003 Wiley‐Liss, Inc.

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