✦ LIBER ✦

Expression of insulin-like growth factor-II and insulin-like growth factor binding proteins during Caco-2 cell proliferation and differentiation

✍ Scribed by Jung H. Y. Park; Mark R. Corkins; Jon A. Vanderhoof; Nia M. Caruso; Marjorie J. Hrbek; Beverly S. Schaffer; Dorothy H. Slentz; Robert H. McCusker; Richard G. MacDonald

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 790 KB
Volume: 166
Category: Article
ISSN: 0021-9541
DOI: 10.1002/(sici)1097-4652(199602)166:2<396::aid-jcp18>3.0.co;2-9

No coin nor oath required. For personal study only.

✦ Synopsis

differentiation is linked to growth of Caco-2 cells, with markers of functional differentiation increasing only after the cells stop proliferating (Pinto e t al., 1983). Given these limitations, Caco-2 cells appear to represent the most relevant in vitro model currently available for study of proliferation and differentiation of small intestinal epithelium .

Recent evidence suggests that specific growth factors may influence Caco-2 cell differentiation (Beaulieu and

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