Insulin and didecanoyl-L-α-phosphatidylcholine: in vitro study of the transport through rabbit nasal mucosal tissue

Epithelial transport and bioavailability

Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with the absorption enhancers didecanoyl-L-α-phosphatidylcholine and α-cyclodextrin in rabbits

✍ Carina Agerholm; Lone Bastholm; Peter B. Johansen; Morten H. Nielsen; Folmer Ell 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 959 KB

The transepithelial transport of biosynthetic human growth hormone (hGH) formulated with the absorption enhancers didecanoylia-phosphatidylcholine (DDPC) and a-cyclodextrin (a-CD) was studied after intranasal administration to rabbits. Plasma concentrations of the hormone were determined until 240 r