✦ LIBER ✦
Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with the absorption enhancers didecanoyl-L-α-phosphatidylcholine and α-cyclodextrin in rabbits
✍ Scribed by Carina Agerholm; Lone Bastholm; Peter B. Johansen; Morten H. Nielsen; Folmer Elling
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 959 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
The transepithelial transport of biosynthetic human growth hormone (hGH) formulated with the absorption enhancers didecanoylia-phosphatidylcholine (DDPC) and a-cyclodextrin (a-CD) was studied after intranasal administration to rabbits. Plasma concentrations of the hormone were determined until 240 rnin post administration by ELISA, and the absolute bioavailability was estimated to be in the vicinity of