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Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification

✍ Scribed by Roland S Hilgarth; Yiling Hong; Ok-Kyong Park-Sarge; Kevin D Sarge


Book ID
117053527
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
174 KB
Volume
303
Category
Article
ISSN
0006-291X

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## Abstract Induction of the heat shock response (HSR), determined by hsp70‐luciferase reporter and HSP70 protein expression, is attenuated as a function of age of the IMR‐90 human diploid fibroblasts. To better understand the underlying mechanism, we evaluated changes in the regulation and functio