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Insights into the Reaction Mechanism of Soluble Epoxide Hydrolase from Theoretical Active Site Mutants

✍ Scribed by Hopmann, Kathrin H.; Himo, Fahmi


Book ID
120626943
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
585 KB
Volume
110
Category
Article
ISSN
0022-3654

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Theoretical Study of the Full Reaction M
✍ Kathrin H. Hopmann; Fahmi Himo πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 698 KB

## Abstract The complete reaction mechanism of soluble epoxide hydrolase (sEH) has been investigated by using the B3LYP density functional theory method. Epoxide hydrolases catalyze the conversion of epoxides to their corresponding vicinal diols. In our theoretical study, the sEH active site is rep