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Insights into the Branched-Chain Formation of Mycarose: Methylation Catalyzed by an (S)-Adenosylmethionine-Dependent Methyltransferase

โœ Scribed by Huawei Chen; Zongbao Zhao; Tina M. Hallis; Zhihong Guo; Hung-wen Liu


Book ID
101364893
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
101 KB
Volume
40
Category
Article
ISSN
0044-8249

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โœฆ Synopsis


A C-methyltransferase involved in methyl-branch formation in sugars has been characterized for the first time. TylC3, an (S)-adenosylmethylthionine(AdoMet)-dependent enzyme, catalyzes the attachment of a methyl branch [Eq. (1)] in the biosynthesis of L-mycarose, an unusual sugar found in tylosin and as its O-3-methyl derivative in erythromycin. The C-3 methylation proceeds with inversion of configuration and does not require the assistance of any cofactors. The turnover rate is 1.4ยฑ0.1 min . TDP=thymidine-5'-dihydrogenphosphate.


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