✦ LIBER ✦

Inositol lipid-mediated cellular signalling

✍ Scribed by Barry V.L. Potter; Roy Gigg

Book ID: 102990277
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 764 KB
Volume: 234
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(92)85034-w

No coin nor oath required. For personal study only.

✦ Synopsis

In 1955, approximately one hundred years after Scherer discovered myo-inositol in a meat extract, approximately twenty years after Henry Dale at the National Institute for Medical Research established the role of acetylcholine as a neurotransmitter, and some ten years after Jordi Folch at the Rockefeller Institute discovered the inositol-containing phospholipids in brain, Lowell and Mabel Hokin, at McGill University, first showed that acetylcholine stimulated the turnover of inositol-containing phospholipids in pancreas and brain cortex slices (see ref. 1 for a personal view of their discovery). Subsequent work showed that this 'phospholipid effect' could be observed in a large number of other systems exposed to a variety of agonists, suggesting a possible role in stimulus-response coupling. At that time one of us (R.G.

📜 SIMILAR VOLUMES

Topology of inositol lipid signal transd

Topology of inositol lipid signal transduction in the nucleus

✍ Nadir M. Maraldi; Nicoletta Zini; Spartaco Santi; Francesco A. Manzoli 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 607 KB

An increasing body of evidence shows that many of the key inositol lipids and enzymes responsible for their metabolism reside in nuclei. Moreover, the association of the nuclear phosphoinositide cycle with progression through the cell cycle and commitment toward differentiation has built a wider pic

Inositol trisphosphate, a novel second m

Inositol trisphosphate, a novel second messenger in cellular signal transduction

✍ Berridge, Michael J.; Irvine, Robin F. 📂 Article 📅 1984 🏛 Nature Publishing Group 🌐 English ⚖ 880 KB

Phosphatidylinositol transfer proteins a

Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling

✍ Ile, Kristina E; Schaaf, Gabriel; Bankaitis, Vytas A 📂 Article 📅 2006 🏛 Nature Publishing Group 🌐 English ⚖ 408 KB

Regulation of lipases by lipid–lipid int

Regulation of lipases by lipid–lipid interactions: implications for lipid-mediated signaling in cells

✍ I.P Sugar; N.K Mizuno; M.M Momsen; W.E Momsen; H.L Brockman 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 268 KB

Toll-like receptor-2 mediates lipopolysa

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

✍ Godowski, Paul J.; Yang, Ruey-Bing; Mark, Melanie R.; Gray, Alane; Huang, Arthur 📂 Article 📅 1998 🏛 Nature Publishing Group 🌐 English ⚖ 338 KB

Toll-like receptor-2 mediates lipopolysa

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

✍ Godowski, Paul J.; Yang, Ruey-Bing; Mark, Melanie R.; Gray, Alane; Huang, Arthur 📂 Article 📅 1998 🏛 Nature Publishing Group 🌐 English ⚖ 338 KB

Vertebrates and invertebrates initiate a series of defence mechanisms following infection by Gram-negative bacteria by sensing the presence of lipopolysaccharide (LPS), a major component of the cell wall of the invading pathogen. In humans, monocytes and macrophages respond to LPS by inducing the ex