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Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells

โœ Scribed by Shamsuddin, Abulkalam M.; Yang, Guang-Yu

Book ID
121687068
Publisher
Oxford University Press
Year
1995
Tongue
English
Weight
459 KB
Volume
16
Category
Article
ISSN
0143-3334

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Inositol hexaphosphate downregulates bot
Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells
โœ Mallikarjuna Gu; Komal Raina; Chapla Agarwal; Rajesh Agarwal ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 322 KB

Constitutively active mitogenic and prosurvival signaling cascades due to aberrant expression and interaction of growth factors and their receptors are well documented in human prostate cancer (PCa). Epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1) are potent mitogens that regu