## Abstract Inosine 5βmonophosphate dehydrogenase II, a key enzyme in the __de novo__ synthesis of purine nucleotides, is expressed in prostate tumors and prostate cancer cells. AVN944 is a new, specific, noncompetitive IMPDH inhibitor. In this study, we investigated the effects of IMPDH inhibitor
β¦ LIBER β¦
Differentiation of Human Prostate Cancer PC-3 Cells Induced by Inhibitors of Inosine 5'-Monophosphate Dehydrogenase
β Scribed by Floryk, D.
- Book ID
- 115481512
- Publisher
- American Association for Cancer Research
- Year
- 2004
- Tongue
- English
- Weight
- 436 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0008-5472
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Human prostatic carcinoma frequently metastasizes to bone tissue and activates bone metabolism, especially bone formation, at the site of metastasis. It has been reported that an extract of prostatic carcinoma and conditioned medium (CM) of a human prostatic carcinoma cell line, PC-3, established fr