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Inositol 1,4,5-trisphosphate and ryanodine receptors mobilize calcium from a common functional pool in human U373 MG cells

โœ Scribed by Maria Galiano; Giuseppe Gasparre; Claudio Lippe; Giuseppe Cassano


Book ID
113525383
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
138 KB
Volume
36
Category
Article
ISSN
0143-4160

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The functional significance of the 2- and 3-hydroxyl groups of 1 D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] was probed by using Ins(1,4,5)P3 analogues variously modified at positions 2 and 3 or elsewhere. The intrinsic activities of these compounds were compared to that of Ins(1,4,5)P3, using