✦ LIBER ✦

Inorganic heparin complexes for the preparation of nonthrombogenic surfaces

✍ Scribed by Dyck, Manfred F.

Publisher: John Wiley and Sons
Year: 1972
Tongue: English
Weight: 828 KB
Volume: 6
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820060211

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✦ Synopsis

The surfaces of many plastics and other materials of interest in the fabrication of implants can be made nonthrombogenic by treating them with an inorganic heparin complex (IHC) system consisting essentially of a soluble metal salt, a solvent, and heparin. During complexing, the metal salt polymerizes at the same time it is trapped in the collapsing matrix of the surface; the entrapped inorganic polymer then reacts with heparin, probably by chelation. Treatment with an IHC system is not known t o alter the mechanical or physical properties of the treated material. If desired, the surface can be made radiopaque by incorporating bismuth chloride or other contrast salts during complexing. After treatment, the surface can be autoclaved or sterilized with ethylene oxide. Materials that have been made nonthrombogenic by the IHC system include Silastic, polyurethane, cellulose acetobutyrate, polymethylmethacrylate, nylon, polyethylene, polypropylene, polyethylene-vinyl acetate, polystyrene, natural rubber, and polyvinyl chloride.

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